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Products Details
Product Description
– LEO 134310 is a selective, non-steroidal glucocorticoid receptor (GR) agonist optimized for topical research., LEO 134310 showed high affinity (EC50 of 14 nM) in a GR binding assay. LEO 134310 can be used for skin diseases[1].
Web ID
– HY-144397
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C34H40N2O8
References
– [1]Stefan Eirefelt, et al. Characterization of a novel non-steroidal glucocorticoid receptor agonist optimized for topical treatment. Sci Rep. 2022 Jan 27;12(1):1501.
CAS Number
– 2089130-74-3
Molecular Weight
– 604.69
SMILES
– O=C([C@@H]1CC(OC1)=O)N(CCC2)C[C@H]2OC(C(C=C3)=CC=C3O[C@H](C4=CC=C(C5CC5)C=C4)[C@H](C)NC([C@H]6CCCO6)=O)=O
Clinical Information
– Phase 1
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Glucocorticoid Receptor
Pathway
– Immunology/Inflammation;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
