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Lenalidomide-C5-amido-Boc
$290 – $880
Products Details
Product Description
– Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC[1].
Web ID
– HY-132856
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture and light)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H31N3O5
References
– [1]Wang, Shaomeng, et al. Preparation of phthalimide-based compounds as monofunctional intermediates for ligand-dependent target protein degradation. World Intellectual Property Organization, WO2017176958 A1 2017-10-12.|[2]Robbins, Daniel, et al. WBifunctional compounds for degrading BTK via ubiquitin proteasome pathway. World Intellectual Property Organization, WO2021091575 A1 2021-05-14.
CAS Number
– 2138441-25-3
Molecular Weight
– 429.51
Compound Purity
– 95.10
SMILES
– O=C(OC(C)(C)C)NCCCCCC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 90 mg/mL (ultrasonic)
Target
– E3 Ligase Ligand-Linker Conjugates
Isoform
– Cereblon
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
