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Leflunomide
$66 – $198
Products Details
Product Description
– Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent.
Web ID
– HY-B0083
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C12H9F3N2O2
References
– [1]Fox RI, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93(3):198-208.|[2]Xu X, et al. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem. 1995 May 26;270(21):12398-403.|[3]Davis JP, et al. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry. 1996 Jan 30;35(4):1270-3.
CAS Number
– 75706-12-6
Molecular Weight
– 270.21
Compound Purity
– 99.72
SMILES
– O=C(C1=C(C)ON=C1)NC2=CC=C(C(F)(F)F)C=C2
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : ≥ 50 mg/mL
Target
– Bacterial;Dihydroorotate Dehydrogenase;Endogenous Metabolite
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
