LDHA/PDKs-IN-1

SKU HY-146977-Get quote Category Tags , ,

Products Details

Product Description

– LDHA/PDKs-IN-1 (compound 20e) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 0.8 and 0.15 μM, respectively. LDHA/PDKs-IN-1 reduces A549 cell proliferation with an EC50 of 13.2 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-1 has the potential for the research of cancer diseases[1].

Web ID

– HY-146977

Shipping

– Room temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C19H21FN2O4

References

– [1]Xiang S, et al. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation. Eur J Med Chem. 2020;203:112579.

CAS Number

– 2490699-40-4

Molecular Weight

– 360.38

SMILES

– CC1=C(C(C=CO1)=O)OCCN2CCN(CC2)C(C3=CC=C(C=C3)F)=O

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– PDK-1

Pathway

– PI3K/Akt/mTOR

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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