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Products Details
Product Description
– LBW242, a 3-mer and Smac mimetic, is a potent and orally active proapoptotic IAP inhibitor. LBW242 shows effects on mutant FLT3-expressing cells. LBW242 has activity against multiple myeloma, and potentiates TRAIL- and anticancer agent-mediated cell death of ovarian cancer cells[1][2].
Web ID
– HY-15519
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H42N4O2
References
– [1]Weisberg E, et al. Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells. Mol Cancer Ther. 2007 Jul;6(7):1951-61.|[2]Petrucci E, et al. A small molecule SMAC mimic LBW242 potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells. PLoS One. 2012;7(4):e35073.
CAS Number
– 867324-12-7
Molecular Weight
– 454.65
SMILES
– [H][C@@]1(C2)[C@](CCN1C([C@H](C3CCCCC3)NC([C@H](C)NC)=O)=O)([H])CCN2CCC4=CC=CC=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FLT3;IAP
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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