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Products Details
Product Description
– Lapatinib (GW572016) tosylate is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].
Web ID
– HY-50898C
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C36H34ClFN4O7S2
References
– [1]Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94
CAS Number
– 1187538-35-7
Molecular Weight
– 753.26
SMILES
– O=S(C1=CC=C(C)C=C1)(O)=O.O=S(CCNCC2=CC=C(C3=CC=C4C(C(NC5=CC(Cl)=C(C=C5)OCC6=CC(F)=CC=C6)=NC=N4)=C3)O2)(C)=O
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Autophagy;EGFR;Ferroptosis
Isoform
– EGFR/ErbB1/HER1;ErbB2/HER2
Pathway
– Apoptosis;Autophagy;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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