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Lapatinib
Price range: 46 CAD through 206 CAD
Products Details
Product Description
– Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity. Lapatinib has antitumor activity and can be used to treat advanced or metastatic breast cancer with HER2 overexpression.
Web ID
– T0078
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C29H26ClFN4O4S
Citations
– 1. Pan Z, Wang K, Wang X, et al. Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression. Molecular Cancer. 2022, 21(1): 1-17.
2. Kang J, Guo Z, Zhang H, et al. Dual Inhibition of EGFR and IGF-1R Signaling Leads to Enhanced Antitumor Efficacy against Esophageal Squamous Cancer. International Journal of Molecular Sciences. 2022, 23(18): 10382
3. Jiang L, Zeng Y, Ai L, et al. Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib. Biochemical Pharmacology. 2022: 115105
4. Zeng R, Yang X M, Li H W, et al.Simplified Derivatives of Tetrandrine as Potent and Specific P-gp Inhibitors to Reverse Multidrug Resistance in Cancer Chemotherapy.Journal of Medicinal Chemistry.2023
5. Sun R, Ge W, Zhu Y, et al.Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets.Molecular & Cellular Proteomics.2023: 100602.
6. Yu T, Zeng R, Guan Y, et al.Discovery of new tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors for reversing multidrug resistance enabled by synthetic methodology-based library.RSC Medicinal Chemistry.2024
7. Abdelaal N, Ragheb M A, Hassaneen H M, et al.Design, in silico studies and biological evaluation of novel chalcones tethered triazolo [3, 4-a] isoquinoline as EGFR inhibitors targeting resistance in non-small cell lung cancer.Scientific Reports.2024, 14(1): 26647.
References
– Wainberg ZA, et al. Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo. Clin Cancer Res. 2010 Mar 1;16(5):1509-19.
CAS Number
– 231277-92-2
Molecular Weight
– C29H26ClFN4O4S
Compound Purity
– 0.9989
SMILES
– N(C=1C2=C(C=CC(=C2)C=3OC(CNCCS(C)(=O)=O)=CC3)N=CN1)C4=CC(Cl)=C(OCC5=CC(F)=CC=C5)C=C4
Target
– Autophagy|||Topoisomerase
Pathway
– Angiogenesis|||Autophagy|||Apoptosis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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