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Product Description
– Laniquidar (R101933) is a noncompetitive, third generation P-glycoprotein (P-gp) inhibitor with an IC50 of 0.51 μM. Laniquidar can be used for modulating multidrug resistance transporters[1]. Laniquidar can also be used for studying acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)[2]. Laniquidar has limited oral bioavailability[3].
Web ID
– HY-132189
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C37H36N4O3
References
– [1]Luurtsema G, et al. Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats. Nucl Med Biol. 2009 Aug;36(6):643-9. |[2]Ross DD. Modulation of drug resistance transporters as a strategy for treating myelodysplastic syndrome. Best Pract Res Clin Haematol. 2004 Dec;17(4):641-51. |[3]Fox E, et al. Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor. Expert Rev Anticancer Ther. 2007 Apr;7(4):447-59.
CAS Number
– 197509-46-9
Molecular Weight
– 584.71
SMILES
– O=C(C1=CN=C2/C(C3=C(CCN21)C=CC=C3)=C4CCN(CC4)CCC5=CC=C(C=C5)OCC6=NC7=C(C=C6)C=CC=C7)OC
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– P-glycoprotein
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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