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Product Description
– Lamotrigine-13C2,15N is the 13C and 15N labeled Lamotrigine[1]. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[2][3].
Web ID
– HY-B0495S3
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C7 13C2H7Cl2N4 15N
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27(5):490-7.|[3]Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv). Apr-Jun 201153(2):57-62.
CAS Number
– 2483830-10-8
Molecular Weight
– 259.07
SMILES
– [15NH2][13C]1=NC(N)=NN=[13C]1C2=C(C(Cl)=CC=C2)Cl
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Autophagy;Sodium Channel
Pathway
– Autophagy;Membrane Transporter/Ion Channel
Product type
– Isotope-Labeled Compounds
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