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Product Description
– Lamotrigine-13C2,15N is the 13C and 15N labeled Lamotrigine[1]. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[2][3].
Web ID
– HY-B0495S3
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C7 13C2H7Cl2N4 15N
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27(5):490-7.|[3]Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv). Apr-Jun 201153(2):57-62.
CAS Number
– 2483830-10-8
Molecular Weight
– 259.07
SMILES
– [15NH2][13C]1=NC(N)=NN=[13C]1C2=C(C(Cl)=CC=C2)Cl
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Autophagy;Sodium Channel
Pathway
– Autophagy;Membrane Transporter/Ion Channel
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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