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Products Details
Product Description
– L5-DA is a G-quadruplex (G4) ligand and selectively stabilized for G4s over ds26. L5-DA exhibits significant cytotoxicity against HeLa cells (IC50=4.3 μM). L5-DA stabilizes G4s in HeLa cells, induces apoptosis, and cell cycle arrest[1].
Web ID
– HY-144712
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C32H34N6O2
References
– [1]Wang Y, et al. A naphthyridine-indole ligand for selective stabilization of G-quadruplexes and conformational conversion of hybrid topology. Bioorg Med Chem. 2021;48:116416.
Molecular Weight
– 534.65
SMILES
– CN(CCOC1=CC2=C(N(C=C2)C3=CC=C4C=CC(N5C=CC6=C5C=CC(OCCN(C)C)=C6)=NC4=N3)C=C1)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;G-quadruplex
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
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