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Products Details
Product Description
– L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO induces a consistentfocal ischemic infarctin rats[2].
Web ID
– HY-100986B
Shipping
– Room temperature
Molecular Formula
– C7H15N3O2
References
– [1]Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9.|[2]Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57.
CAS Number
– 36889-13-1
Molecular Weight
– 173.21
SMILES
– CC(NCCC[C@@H](C(O)=O)N)=N
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– NO Synthase
Pathway
– Immunology/Inflammation
Product type
– Reference compound
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