Download Files:
Products Details
Product Description
– L-Kynurenine-13C10 (sulfate) is the 13C labeled L-Kynurenine sulfate[1]. L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype[2].
Web ID
– HY-104026BS
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– 13C10H7N2O7S
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Benjamin J Moyer, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24.
Molecular Weight
– 309.16
SMILES
– O[13C]([13C@@](N)[13C][13C]([13C]1=[13C]([13C]=[13C][13C]=[13C]1)N)=O)=O.O=S(O)(O)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Aryl Hydrocarbon Receptor;Endogenous Metabolite
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
