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Products Details
Product Description
– L-869298 is a potent and selective PDE4 inhibitor with an IC50 of 0.5 nM for PDE4A. L-869298 shows less active against hERG potassium channel[1].
Web ID
– HY-122167
Shipping
– Room temperature
Molecular Formula
– C23H18F8N2O4S
References
– [1]Richard W Friesen, et al. Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity. J Med Chem. 2003 Jun 5;46(12):2413-26.
CAS Number
– 362718-73-8
Molecular Weight
– 570.45
SMILES
– OC(C(F)(F)F)(C1=NC=C(S1)[C@@H](CC2=C[N+]([O-])=CC=C2)C3=CC=C(C(OC4CC4)=C3)OC(F)F)C(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE)
Isoform
– PDE4
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
