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L-2-Hydroxyglutaric acid
$240
Only 1000 item(s) left in stock.
Products Details
Product Description
– L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].
Web ID
– HY-113039
Storage Temperature
– Solution, -20°C, 2 years
Shipping
– Blue Ice
Applications
– Cancer-Kinase/protease
Molecular Formula
– C5H8O5
References
– [1]Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8.|[2]da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21(4):217-24.
CAS Number
– 13095-48-2
Molecular Weight
– 148.11
Compound Purity
– 95.0
SMILES
– O=C(O)[C@@H](O)CCC(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;Histone Demethylase;Mitochondrial Metabolism
Isoform
– Human Endogenous Metabolite
Pathway
– Epigenetics;Metabolic Enzyme/Protease
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
