L 152804

$90$750

Products Details

Product Description

– L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure[1][2].

Web ID

– HY-107734

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Metabolism-protein/nucleotide metabolism

Molecular Formula

– C23H26O4

References

– [1]Kanatani A, et al. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73.|[2]Mashiko S, et al. A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol Pharmacol. 2007 Feb;71(2):602-8. Epub 2006 Nov 14.

CAS Number

– 6508-43-6

Molecular Weight

– 366.45

Compound Purity

– 99.48

SMILES

– O=C1C2=C(CC(C)(C)C1)OC3=CC=CC=C3C2C4C(CC(C)(C)CC4=O)=O

Clinical Information

– No Development Reported

Research Area

– Metabolic Disease; Endocrinology

Solubility

– DMSO : ≥ 125 mg/mL

Target

– Neuropeptide Y Receptor

Isoform

– NPY Y5 receptor

Pathway

– GPCR/G Protein;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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