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L 152804
SKU
HY-107734-10 mg
Category Reference compound
Tags GPCR/G Protein;Neuronal Signaling, Metabolic Disease; Endocrinology, Neuropeptide Y Receptor
$90 – $750
Products Details
Product Description
– L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure[1][2].
Web ID
– HY-107734
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C23H26O4
References
– [1]Kanatani A, et al. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73.|[2]Mashiko S, et al. A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol Pharmacol. 2007 Feb;71(2):602-8. Epub 2006 Nov 14.
CAS Number
– 6508-43-6
Molecular Weight
– 366.45
Compound Purity
– 99.48
SMILES
– O=C1C2=C(CC(C)(C)C1)OC3=CC=CC=C3C2C4C(CC(C)(C)CC4=O)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Endocrinology
Solubility
– DMSO : ≥ 125 mg/mL
Target
– Neuropeptide Y Receptor
Isoform
– NPY Y5 receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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