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Kynurenic acid
$55 – $77
Products Details
Product Description
– Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
Web ID
– HY-100806
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C10H7NO3
References
– [1]Małaczewska J, et al. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol. 2014;39(1):6-13.|[2]Wang J, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281(31):22021-8.|[3]Albuquerque EX, et al. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol. 2013 Apr 15;85(8):1027-32.
CAS Number
– 492-27-3
Molecular Weight
– 189.17
Compound Purity
– 99.58
SMILES
– O=C(C1=NC2=CC=CC=C2C(O)=C1)O
Clinical Information
– Phase 1
Research Area
– Inflammation/Immunology; Neurological Disease; Endocrinology
Solubility
– 0.1 M NaOH : 12.5 mg/mL (ultrasonic;adjust pH to 9 with NaOH)|DMSO : 9 mg/mL (ultrasonic;warming)
Target
– Apoptosis;CXCR;Endogenous Metabolite;GPR35 ;iGluR
Isoform
– Human Endogenous Metabolite;NMDA Receptor
Pathway
– Apoptosis;GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
