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Products Details
Product Description
– Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3].
Web ID
– HY-117010
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C26H32O8
References
– [1]Yannan Li, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.|[2]E R Woo, et al. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod. 1998 Dec;61(12):1552-4.|[3]Seizo Sato, et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.
CAS Number
– 101236-49-1
Molecular Weight
– 472.53
SMILES
– COC(C=C1O)=C(C2=O)C(O[C@H](C(C=CC(O)=C3)=C3O)[C@@H]2O)=C1C[C@H](C(C)=C)CCC(C)(O)C
Clinical Information
– No Development Reported
Research Area
– Infection; Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Cytochrome P450;HSV;SGLT
Isoform
– CYP3;HSV-2;SGLT1;SGLT2
Pathway
– Anti-infection;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Natural Products
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