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Products Details
Product Description
– Kukoamine A-d8 (dihydrochloride) is deuterium labeled Kukoamine A. Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].
Web ID
– HY-N2392S
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C28H36D8Cl2N4O6
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Ponasik JA, et al. Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. Biochem J. 1995 Oct 15;311 ( Pt 2):371-5.
Molecular Weight
– 611.63
SMILES
– [2H]C([2H])(NCCCNC(CCC1=CC=C(O)C(O)=C1)=O)C([2H])([2H])C([2H])([2H])C([2H])(NCCCNC(CCC2=CC=C(O)C(O)=C2)=O)[2H].Cl.Cl
Clinical Information
– No Development Reported
Research Area
– Infection; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Isotope-Labeled Compounds;Parasite
Isoform
– Trypanosoma
Pathway
– Anti-infection;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
