![](https://immunomart.com/wp-content/uploads/2024/03/HY-12061.gif)
Download Files:
KU-60019
SKU
HY-12061-10 mg
Category Reference compound
Tags ATM/ATR, Cancer, Cell Cycle/DNA Damage;PI3K/Akt/mTOR
$92 – $660
Products Details
Product Description
– KU-60019 is an improved ATM kinase-specific inhibitor with IC50 of 6.3 nM.
Web ID
– HY-12061
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C30H33N3O5S
References
– [1]Golding SE, et al. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8(10):2894-902.|[2]McCabe N, et al. Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM. Cancer Res. 2015 Jun 1;75(11):2159-65.
CAS Number
– 925701-46-8
Molecular Weight
– 547.67
Compound Purity
– 99.43
SMILES
– C[C@@H]1O[C@@H](CN(CC(NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(C=C(O5)N6CCOCC6)=O)=O)C1)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)|Ethanol : 10 mg/mL (ultrasonic)
Target
– ATM/ATR
Isoform
– ATM
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.