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Products Details
Product Description
– KRN5500 (NSC 650426), a Spicamycin (HY-127130) derivative and a nucleoside-like antibiotic with anti-tumor activity. KRN5500 also induces apoptosis via the down-regulation of Bcl-2 expression. KRN5500 shows a significant efficacy in the human tumor xenograft model in mice[1][2].
Web ID
– HY-13659
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C28H43N7O7
References
– [1]Kamishohara M, et al. Antitumor activity of a spicamycin derivative, KRN5500, and its active metabolite in tumor cells. Oncol Res. 1994;6(8):383-90. |[2]Zhang WJ, et al. Spicamycin and KRN5500 induce apoptosis in myeloid and lymphoid cell lines with down-regulation of bcl-2 expression and modulation of promyelocytic leukemia protein. Jpn J Cancer Res. 2000 Jun;91(6):604-11.
CAS Number
– 151276-95-8
Molecular Weight
– 589.68
SMILES
– O[C@@H]1[C@H](O)[C@@H](NC(CNC(/C=C/C=C/CCCCCCCCC)=O)=O)[C@]([H])([C@@H](O)CO)O[C@@H]1NC2=NC=NC3=C2NC=N3
Clinical Information
– Phase 2
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Apoptosis;Bcl-2 Family
Isoform
– Bcl-2
Pathway
– Anti-infection;Apoptosis
Product type
– Reference compound
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