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Products Details
Product Description
– KRAS inhibitor-20 is a small molecular inhibitor of KRasG12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRasG12C with the IC50 value <10 nM[1].
Web ID
– HY-151287
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C31H40F4N6O2
References
– [1]Kargbo RB. Small-Molecule Inhibitor of the Oncogenic KRASG12CÂ Mutant for the Treatment of Currently Incurable Cancer. ACS Med Chem Lett. 2022 Apr 20;13(5):767-769.Â
CAS Number
– 2411786-32-6
Molecular Weight
– 604.68
SMILES
– C[C@H]1CN(C(C=C)=O)CCN1C2=NC(OC[C@H]3N(CCC3)C)=NC4=C2C[C@@H](C)[C@H](C5=C(F)C(N)=CC(C)=C5C(F)(F)F)C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ras
Isoform
– K-Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
