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Products Details
Product Description
– KRAS inhibitor-16 (compound 3-11) is a potent KRAS G12C inhibitor with an IC50 of 0.457 µM. KRAS inhibitor-16 shows p-ERK inhibition activities with IC50s of 3.06, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-16 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
Web ID
– HY-146546
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H16Cl2FN3O2S
References
– [1]Brian Alan LANMAN, et al. Kras g12c inhibitors and methods of using the same. US20180334454A1.
CAS Number
– 2230873-67-1
Molecular Weight
– 452.33
SMILES
– C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(O)=CC=C4Cl)=C(C3=NS2)F)Cl)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ras
Isoform
– K-Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
