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KRas G12R inhibitor 1
$590 – $2,080
Products Details
Product Description
– KRas G12R inhibitor 1 (compound 3) is a KRas G12R selective covalent inhibitor that exploits the strong nucleophilicity of mutant cysteines and binds irreversibly in the Switch II region of K-Ras. KRas G12R inhibitor 1 can be used in cancer research[1].
Web ID
– HY-151523
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C39H38ClF7N6O9
References
– [1]Ziyang Zhang, et al. Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile. J Am Chem Soc. 2022 Sep 7;144(35):15916-15921.Â
Molecular Weight
– 903.20
Compound Purity
– 98.19
SMILES
– CC(C(O)(O)C(N1[C@@H]2CC[C@H]1CN(C3=NC(OCC45CCCN4CCC5)=NC6=C3C=NC(C7=C8C(Cl)=CC=CC8=CC=C7)=C6F)C2)=O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
