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Products Details
Product Description
– KRAS G12C inhibitor 57 (Compound 50) is a potent, selective, covalent and orally active KRAS G12C inhibitor with an IC50 of 0.21 μM in KRAS G12C/SOS1 binding assay. KRAS G12C inhibitor 57 induces cancer cell apoptosis[1].
Web ID
– HY-151968
Shipping
– Room temperature
Molecular Formula
– C35H38FN7O2
References
– [1]Song Z, et al. Identification of novel Pyrrolo [2, 3-d] Pyrimidine-based KRAS G12C inhibitors with anticancer effects. European Journal of Medicinal Chemistry, 2022: 114907.
CAS Number
– 2821863-70-9
Molecular Weight
– 607.72
SMILES
– N#CC[C@@H]1N(C(C=C)=O)CCN(C2=C3C(N(C)C(C4=C5C(C)=CC=CC5=CC=C4)=C3)=NC(OC[C@@]67CCCN6C[C@H](F)C7)=N2)C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ras
Isoform
– K-Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
