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Products Details
Product Description
– KRAS G12C inhibitor 47 (compound 8-1-1) is a potent KRAS G12C inhibitor with an IC50 of 0.172 µM. KRAS G12C inhibitor 47 shows p-ERK inhibition activities with IC50s of 0.046, 69.8 µM in MIA PaCA-2, A549 cells, respectively. KRAS G12C inhibitor 47 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
Web ID
– HY-146537
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C30H28ClFN4O3
References
– [1]Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2
CAS Number
– 2253119-24-1
Molecular Weight
– 547.02
SMILES
– O=C1N=C(N2CCN(CC2)C(C=C)=O)C3=C(N1C4=C(C(C)C)C=CC=C4)C=C(C5=C(O)C=CC=C5F)C(Cl)=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ras
Isoform
– K-Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
