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Products Details
Product Description
– KRAS G12C inhibitor 44 (compound 54) is a potent and orally active KRAS G12C inhibitor. KRAS G12C inhibitor 44 shows anti-proliferation activities with IC50s of 0.016, 0.028 µM in MIA PaCA-2, H358 cells, respectively. KRAS G12C inhibitor 44 shows antitumor effects in vivo[1].
Web ID
– HY-142946
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C31H36ClFN6O2
References
– [1]Li Chao, et al. Spirocyclic tetrahydroquinazolines. WO2021139748A1.
CAS Number
– 2927439-07-2
Molecular Weight
– 579.11
SMILES
– ClC1=C2C([C@]3(CC2)CC4=NC(OC[C@H]5N(CCC5)C)=NC(N6C[C@@H](N(CC6)C(C(F)=C)=O)CC#N)=C4CC3)=CC=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ras
Isoform
– K-Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
