Download Files:
KNT-127
$450 – $5,200
Products Details
Product Description
– KNT-127 is a potent and selective δ-opioid receptor agonist effective by systemic administration. KNT-127 shows selectivity for the δ-receptor (Ki 0f 21.3, 0.16, 153 nM for opioid μ-, δ-, and κ-receptors, respectively). KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex. Antidepressant-like effects[1][2].
Web ID
– HY-120511
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C24H24N2O2
References
– [1]Nagase H, et al. Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration. Bioorg Med Chem Lett. 2010;20(21):6302-6305. |[2]Tanahashi S, et al. Novel δ1-receptor agonist KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex. Neuropharmacology. 2012;62(5-6):2057-2067.
CAS Number
– 1256921-89-7
Molecular Weight
– 372.46
Compound Purity
– 99.60
SMILES
– O[C@@]12[C@]3(CC4=NC5=CC=CC=C5C=C4C2)C6=CC(O)=CC=C6C[C@H]1N(CC3)C
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 25 mg/mL (ultrasonic)
Target
– Opioid Receptor
Isoform
– δ Opioid Receptor/DOR
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
