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Products Details
Product Description
– KIRA9 is a potent IRE1 inhibitor (IC50=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis[1].
Web ID
– HY-145422
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H27F3N6O3S
References
– [1]Feldman HC, et al. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nat Chem Biol. 2021;17(11):1148-1156.
CAS Number
– 2922507-65-9
Molecular Weight
– 572.60
SMILES
– O=S(NC1=CC=C(OC2=NC=CC=C2C3=CC=NC(N[C@@H]4CNCCC4)=N3)C5=C1C=CC=C5)(CCC(F)(F)F)=O
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Apoptosis;IRE1
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
