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Khellin
$30 – $40
Products Details
Product Description
– Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects[1][2].
Web ID
– HY-B1394
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C14H12O5
References
– [1]Abdel-Sattar S Hamad Elgazwy, et al. Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors. J Enzyme Inhib Med Chem. 2013 Dec;28(6):1171-81.|[2]A Ubeda, et al. Relaxant actions of khellin on vascular smooth muscle. J Pharm Pharmacol . 1989 Apr;41(4):236-41.
CAS Number
– 82-02-0
Molecular Weight
– 260.24
Compound Purity
– 99.89
SMILES
– O=C1C=C(C)OC2=C(OC)C(OC=C3)=C3C(OC)=C12
Clinical Information
– No Development Reported
Research Area
– Cancer; Cardiovascular Disease
Solubility
– DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
