Download Files:
Products Details
Product Description
– KH-259 (compound 1) is a potent, selective and CNS-penetrant HDAC6 inhibitor, with an IC50 of 0.26 μM. KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain. KH-259 can be used for neurodegenerative diseases research[1].
Web ID
– HY-150503
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C20H25N3O2
References
– [1]Kosuke Hashimoto, et al. Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors. ACS Med. Chem. Lett. 2022 June 28.
Molecular Weight
– 339.43
SMILES
– CC(N1CCN(CC2=CC=C(C(NO)=O)C=C2)CC1)C3=CC=CC=C3
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– HDAC
Isoform
– HDAC1;HDAC4;HDAC6
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
