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Keap1-Nrf2-IN-6

SKU HY-143893-Get quote Category Reference compound Tags Inflammation/Immunology, Keap1-Nrf2, NF-κB

Products Details

Product Description

– Keap1-Nrf2-IN-6 (compound 64) is a potent and selective Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 41 nM, Kd of 68 nM[1].

Web ID

– HY-143893

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C30H34N4O8S

References

– [1]Begnini F, et al. Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. J Med Chem. 2022 Feb 24;65(4):3473-3517.

Molecular Weight

– 610.68

SMILES

– O=C1N[C@H](CSCC2=C(C(OC[C@H]1NC([C@@H]3CCCN3C(C)=O)=O)=O)C=CC=C2C4=CC=C(C=C4)C(O)=O)C(N(C)C)=O

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– Keap1-Nrf2

Pathway

– NF-κB

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.