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Products Details
Product Description
– Keap1-Nrf2-IN-5 (compound 1) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 4.1 µM, Kd of 3.7 µM[1].
Web ID
– HY-143892
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H30N4O6S
References
– [1]Begnini F, et al. Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. J Med Chem. 2022 Feb 24;65(4):3473-3517.
CAS Number
– 2696272-70-3
Molecular Weight
– 490.57
SMILES
– O=C([C@H](NC([C@H](NC([C@H]1N(C(C)=O)CCC1)=O)CO2)=O)CSCC3=CC=CC=C3C2=O)N(C)C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Keap1-Nrf2
Pathway
– NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
