KDOAM-25 (trihydrochloride)

SKU HY-102047A-Get quote Category Tags , ,

Products Details

Product Description

– KDOAM-25 trihydrochloride is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells[1].

Web ID

– HY-102047A

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C15H28Cl3N5O2

References

– [1]Tumber A, et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol. 2017 Mar 16;24(3):371-380.

Molecular Weight

– 416.77

SMILES

– NC(C1=CC=NC(CNCC(N(CC)CCN(C)C)=O)=C1)=O.Cl.Cl.Cl

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Histone Demethylase

Isoform

– KDM5

Pathway

– Epigenetics

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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