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KDM5-C49 (hydrochloride)
$150 – $1,350
Products Details
Product Description
– KDM5-C49 (KDOAM-20) hydrochloride is a potent and selective inhibitor of KDM5 demethylases, with IC50s of 40 nM, 160 nM, and 100 nM for KDM5A, KDM5B, and KDM5C enzymes, respectively. KDM5-C49 hydrochloride can be used for the research of cancer[1].
Web ID
– HY-119397A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H25ClN4O3
References
– [1]Horton JR, et, al. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol. 2016 Jul 21;23(7):769-781.|[2]Song YQ, et al. The role and prospect of lysine-specific demethylases in cancer chemoresistance. Med Res Rev. 2023 Apr 3.
Molecular Weight
– 344.84
Compound Purity
– 99.95
SMILES
– O=C(C1=CC=NC(CNCC(N(CC)CCN(C)C)=O)=C1)O.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Histone Demethylase
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
