KDM4-IN-2

SKU HY-128343-10 mg Category Tags , ,

$820$6,900

Products Details

Product Description

– KDM4-IN-2 (Compound 19a) is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively[1].

Web ID

– HY-128343

Storage Temperature

– 4°C (Powder, sealed storage, away from moisture and light)

Shipping

– Room Temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C25H26N6O

References

– [1]Le Bihan YV, et al. C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur J Med Chem. 2019 Sep 1;177:316-337.

CAS Number

– 2369607-62-3

Molecular Weight

– 426.51

Compound Purity

– 98.29

SMILES

– O=C1C2=CC=NC(N3C=C(CCN4CCC5(CCC6=C5C=CC=C6)CC4)C=N3)=C2N=CN1

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 4 mg/mL (ultrasonic;warming;heat to 60°C)

Target

– Histone Demethylase

Isoform

– KDM4

Pathway

– Epigenetics

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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