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KDM1/CDK1-IN-1

Products Details

Product Description

– KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC50 values of 16.34, 3.45 and 7.79 μM, respectively[1].

Web ID

– HY-147901

Shipping

– Room temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C22H17N5O3S

References

– [1]Husseiny EM. Synthesis, cytotoxicity of some pyrazoles and pyrazolo[1,5-a]pyrimidines bearing benzothiazole moiety and investigation of their mechanism of action. Bioorg Chem. 2020 Sep;102:104053.

CAS Number

– 2938990-92-0

Molecular Weight

– 431.47

SMILES

– O=C(C1=C(O)N2C(N=C1)=C(C3=NC4=CC=CC=C4S3)C(NC5=CC=CC=C5)=N2)OCC

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Apoptosis;Caspase;CDK;Histone Demethylase

Isoform

– Caspase 3;CDK1;KDM1/LSD1

Pathway

– Apoptosis;Cell Cycle/DNA Damage;Epigenetics

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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