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KDM1/CDK1-IN-1
SKU
HY-147901-Get quote
Category Reference compound
Tags Apoptosis;Caspase;CDK;Histone Demethylase, Apoptosis;Cell Cycle/DNA Damage;Epigenetics, Cancer
Products Details
Product Description
– KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC50 values of 16.34, 3.45 and 7.79 μM, respectively[1].
Web ID
– HY-147901
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H17N5O3S
References
– [1]Husseiny EM. Synthesis, cytotoxicity of some pyrazoles and pyrazolo[1,5-a]pyrimidines bearing benzothiazole moiety and investigation of their mechanism of action. Bioorg Chem. 2020 Sep;102:104053.
CAS Number
– 2938990-92-0
Molecular Weight
– 431.47
SMILES
– O=C(C1=C(O)N2C(N=C1)=C(C3=NC4=CC=CC=C4S3)C(NC5=CC=CC=C5)=N2)OCC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Caspase;CDK;Histone Demethylase
Isoform
– Caspase 3;CDK1;KDM1/LSD1
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.