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kb NB 142-70
$119 – $851
Products Details
Product Description
– kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also has antitumor activity.
Web ID
– HY-15528
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C11H9NO2S2
References
– [1]Lavalle CR, et al. Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility. BMC Chem Biol. 2010 May 5;10:5.|[2]James Sinnett-Smith, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15; 306(10): C961-C971.
CAS Number
– 1233533-04-4
Molecular Weight
– 251.32
Compound Purity
– 98.08
SMILES
– O=C1NCCSC2=C1SC3=CC=C(O)C=C32
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 46.67 mg/mL (ultrasonic)
Target
– PKD
Isoform
– PKD1;PKD2;PKD3
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
