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Karenitecin
$510 – $3,750
Products Details
Product Description
– Karenitecin (Cositecan) is a topoisomerase I inhibitor, with potent anti-cancer activity.
Web ID
– HY-14812
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H28N2O4Si
References
– [1]Yin MB, et al. Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350. Mol Pharmacol. 2000 Mar;57(3):453-9.|[2]Van Hattum AH, et al. New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer. Int J Cancer. 2000 Oct 15;88(2):260-6.
CAS Number
– 203923-89-1
Molecular Weight
– 448.59
Compound Purity
– 98.27
SMILES
– O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC[Si](C)(C)C)C5=CC=CC=C5N=C4C3=C2)=O
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– DMSO : 3.03 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Topoisomerase
Isoform
– Topo I
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
