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Product Description
– Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia[1][2][3][4].
Web ID
– HY-16566
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C18H36N4O11
Citations
– Food Chem. 2022 Sep 26;403:134399.|Int J Med Microbiol. 2023 Mar 28;313(2):151578.|ACS Chem Biol. 2021 Dec 15.|Cell Death Dis. 2021 May 18;12(6):509.|Int J Hydrogen Energy. 2018, 43(30), 13821-13828.|Microb Biotechnol. 2021 Mar 15.|Nucleic Acids Res. 2022 Dec 12;gkac1141.|Sci Adv. 2023 Feb 17;9(7):eade4770.
References
– [1]YANAGISAWA K, et al. Studies on kanamycin, a new antibiotic against tubercle bacilli. I. Effect on virulent tubercle bacilli in vitro and in mice. J Antibiot (Tokyo). 1957 Nov;10(6):233-5. |[2]Nishi T, et al. Experimental respiratory tract infection with Klebsiella pneumoniae DT-S in mice: chemotherapy with kanamycin. Antimicrob Agents Chemother. 1980 Mar;17(3):494-505.|[3]Misumi M, et al. Interaction of kanamycin and related antibiotics with the large subunit of ribosomes and the inhibition of translocation. Biochem Biophys Res Commun. 1978 Sep 29;84(2):358-65. |[4]Misumi M, et al. Mechanism of inhibition of translocation by kanamycin and viomycin: a comparative study with fusidic acid. Biochem Biophys Res Commun. 1980 Jan 29;92(2):647-54.
CAS Number
– 59-01-8
Molecular Weight
– 484.50
SMILES
– O[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)([H])O[C@H](CN)[C@@H](O)[C@@H]1O
Clinical Information
– Launched
Research Area
– Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Bacterial
Isoform
– Aminoglycoside
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
