Download Files:
Products Details
Product Description
– K-7174 is an orally active proteasome and GATA inhibitor. K-7174 is a cell adhesion inhibitor. K-7174 induces cell apoptosis. K-7174 shows antitumor activities, it can be used for the research of cancer[1][2][3].
Web ID
– HY-12743
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C33H48N2O6
Citations
– Brain Res. 2022.|FEBS Open Bio. 2020 Sep;10(9):1880-1890.|Research Square Preprint. 2020 Dec.|Biomaterials. 2021, 120967.|bioRxiv. 2019 Sep.|Cell Rep Med. 2022 Mar 15;3(3):100561.|Department of Molecular Medicine and Biopharmaceutical Sciences. 2020 May.|FASEB J. 2020 Mar;34(3):4462-4481.
References
– [1]Umetani M, et al. A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATA. Biochem Biophys Res Commun. 2000 Jun 7;272(2):370-4.|[2]Imagawa S, et al. A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA. FASEB J. 2003 Sep;17(12):1742-4.|[3]Kikuchi J, et al. The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases. J Biol Chem. 2013 Aug 30;288(35):25593-602.
CAS Number
– 191089-59-5
Molecular Weight
– 568.74
SMILES
– COC1=C(OC)C(OC)=CC(/C=C/CCCN2CCN(CCC/C=C/C3=CC(OC)=C(OC)C(OC)=C3)CCC2)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Proteasome
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
