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Products Details
Product Description
– JTP-4819 is a potent and specific inhibitor of prolyl endopeptidase (PREP) with IC50s of 0.83 nM (in rat brain supernatant) and 5.43 nM (in Flavobacterium meningosepticum). JTP-4819 has blood-brain penetration, also improves the retention time of amnesia rats induced by Scopolamine (HY-N2096)[1][2].
Web ID
– HY-15112
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C19H25N3O4
References
– [1]Toide K, et al. JTP-4819: a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer. J Pharmacol Exp Ther. 1995 Sep;274(3):1370-8.
CAS Number
– 162203-65-8
Molecular Weight
– 359.42
SMILES
– O=C(N1[C@H](C(N2[C@H](C(CO)=O)CCC2)=O)CCC1)NCC3=CC=CC=C3
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Prolyl Endopeptidase (PREP)
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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