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Products Details
Product Description
– JNK3 inhibitor-5 (Compound 22b) is a potent and selective JNK3 inhibitor with an IC50 of 0.379 nM. JNK3 inhibitor-5 effectively protects the neuronal cells against amyloid beta-induced apoptosis. JNK3 inhibitor-5 has a high cell permeability and is predicted as BBB permeable[1].
Web ID
– HY-151962
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C26H27Cl2N7O2
References
– [1]Jun J, et al. Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114917.
CAS Number
– 2911640-63-4
Molecular Weight
– 540.44
SMILES
– NC(C1CC2=C(C1)N=C(C3=CC(Cl)=C(C=C3)Cl)N2C4=NC(N[C@@H]5CN(CCC5)C(C6CC6)=O)=NC=C4)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;GSK-3;JNK;p38 MAPK
Isoform
– GSK-3β;JNK1;JNK2;JNK3;p38α
Pathway
– Apoptosis;MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
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