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Products Details
Product Description
– JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM. JNJ-4355 shows antitumor activity[1][2].
Web ID
– HY-150507
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C40H43ClFN5O5S
References
– [1]Matthieu Jouffroy, et al. Synthesis of Atropisomeric Biaryls via Chiral Suzuki–Miyaura/Enzymatic Kinetic Resolution. ACS Catal. 2022, 12, 8380–8385.|[2]Frederik J. Rombouts, et al. Abstract 2133: In pursuit of MCL-1 inhibitors with improved therapeutic window for the treatment of hematological malignancies: Discovery of JNJ-4355. Cancer Res (2022) 82 (12_Supplement): 2133.
CAS Number
– 2697112-32-4
Molecular Weight
– 760.32
SMILES
– ClC1=CC=C2C(C(C)=C(N2CCCO3)C(O)=O)=C1C(C(C)=NN4CCOCCOC)=C4CSCC5=NN(C)C(CCC6=CC(C=C(F)C=C7)=C7C3=C6)=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcl-2 Family
Isoform
– Mcl-1
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
