Download Files:
JNJ-40418677
$130 – $390
Products Details
Product Description
– JNJ-40418677 is an orally active modulator of γ-secretase, can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease, with IC50s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimer’s disease research[1][2][3].
Web ID
– HY-100604
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C26H22F6O2
References
– [1]Van Broeck B, et al. Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer’s disease. Br J Pharmacol. 2011 May;163(2):375-89. |[2]Harrie J.M. Gijsen, et al. Chapter Five – Secretase Inhibitors and Modulators as a Disease-Modifying Approach Against Alzheimer’s Disease. Annu Rep Med Chem. 2012. 47:55-69.|[3]Samrat SK, et al. Antiviral Agents against Flavivirus Protease: Prospect and Future Direction. Pathogens. 2022 Feb 25;11(3):293.
CAS Number
– 1146594-87-7
Molecular Weight
– 480.44
Compound Purity
– 99.0
SMILES
– CC(C)C[C@@H](C1=CC(C2=CC=C(C=C2)C(F)(F)F)=CC(C3=CC=C(C=C3)C(F)(F)F)=C1)C(O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Amyloid-β;γ-secretase
Pathway
– Neuronal Signaling;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
