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Products Details
Product Description
– JNJ-27141491 is a selective, noncompetitive and orally active functional antagonist of human CCR2[1].
Web ID
– HY-110132
Shipping
– Room temperature
Molecular Formula
– C17H15F2N3O3S
References
– [1]Buntinx M, et al. Pharmacological profile of JNJ-27141491 [(S)-3-[3,4-difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl acid methyl ester], as a noncompetitive and orally active antagonist of the human chemokine receptor CCR2. J Pharmacol Exp Ther. 2008 Oct;327(1):1-9.
CAS Number
– 871313-59-6
Molecular Weight
– 379.38
SMILES
– CC[C@@H](C1=CC(F)=C(F)C=C1)N2C(C(OC)=O)=C(C3=CC=NO3)NC2=S
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– CCR
Isoform
– CCR2
Pathway
– GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
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