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Products Details
Product Description
– JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor[1].
Web ID
– HY-103538
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C10H8ClNO3
References
– [1]Marine Peuchmaur, et al. Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein. Bioorg Med Chem. 2013 Feb 15;21(4):1018-29.
CAS Number
– 62252-26-0
Molecular Weight
– 225.63
SMILES
– O=C1C2=CC(N)=CC=C2C(Cl)=C(OC)O1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Amyloid-β
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
