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Products Details
Product Description
– JH-XIV-68-3 is a selective macrocyclic inhibitor of DYRK1A/B. JH-XIV-68-3 displays selectivity for DYRK1A and close family member DYRK1B in biochemical and cellular assays. JH-XIV-68-3 demonstrates antitumor efficacy in head and neck squamous cell carcinoma (HNSCC) cell lines[1].
Web ID
– HY-144617
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H19F3N8O
References
– [1] Powell CE, et al. Selective Macrocyclic Inhibitors of DYRK1A/B. ACS Med Chem Lett. 2022;13(4):577-585.
CAS Number
– 2426628-29-5
Molecular Weight
– 468.43
SMILES
– FC(F)(F)C1=NN2C=C1C3=CNC4=NC=C(C=C43)C5=C(C#N)N(C)N=C5CN(C)C(CCC2)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DYRK
Isoform
– DYRK1
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
