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Products Details
Product Description
– JE-2147 (AG1776) is a potent dipeptide protease inhibitor with a Ki of 0.33 nM for HIV-1 protease. JE-2147 has effective activities against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro[1][2].
Web ID
– HY-100212
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C32H37N3O5S
References
– [1]Yoshimura K, et al. JE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8675-80.|[2]Mimoto T, et al. Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine. J Med Chem. 1999 May 20;42(10):1789-802.
CAS Number
– 186538-00-1
Molecular Weight
– 575.72
SMILES
– CC(C=CC=C1)=C1CNC([C@H]2N(CSC2(C)C)C([C@@H](O)[C@@H](NC(C3=C(C(O)=CC=C3)C)=O)CC4=CC=CC=C4)=O)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– HIV;HIV Protease
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
