Download Files:
Web ID
– HY-10486
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C28H39N3O3
References
– [1]Thomas, James B. et al. Importance of Phenolic Address Groups in Opioid Kappa Receptor Selective Antagonists. Journal of Medicinal Chemistry (2004), 47(4), 1070-1073.|[2]Jackson KJ, Carroll FI, Negus SS, Damaj MI.
Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse.
Psychopharmacology (Berl). 2010 Jun;210(2):285-94.|[3]Beardsley PM, Pollard GT, Howard JL, Carroll FI.
Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diuresis and stress-induced cocaine reinstatement in rats.
Psychopharmacology (Berl). 2010 Jun;210(2):189-98.|[4]Deehan GA Jr, McKinzie DL, Carroll FI, McBride WJ, Rodd ZA.
The long-lasting effects of JDTic, a kappa opioid receptor antagonist, on the expression of ethanol-seeking behavior and the relapse drinking of female alcohol-preferring (P) rats.
Pharmacol Biochem Behav. 2012 Jun;101(4):581-7.|[5]Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC.
Structure of the human κ-opioid receptor in complex with JDTic.
Nature. 2012 Mar 21;485(7398):327-32. doi: 10.1038/nature10939.
CAS Number
– 361444-66-8
Molecular Weight
– 465.63
SMILES
– O=C([C@@H]1NCC2=C(C=CC(O)=C2)C1)N[C@@H](C(C)C)CN3C[C@H](C)[C@](C)(C4=CC=CC(O)=C4)CC3
Clinical Information
– Phase 1
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Opioid Receptor
Isoform
– κ Opioid Receptor/KOR
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
