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Products Details
Product Description
– JDB175 is a highly selective BTK inhibitor with oral activity and excellent blood-brain barrier penetration. JDB175 shows good activity in the mouse model of central nervous system lymphoma without obvious signs of toxicity, effectively inhibits the proliferation of BTK signaling pathway of human lymphoma cells, induces cell cycle arrest, and promotes cell apoptosis [1].
Web ID
– HY-157156
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H21F3N4O2
References
– [1]Xia Y, et al. A novel Bruton’s tyrosine kinase inhibitor JDB175 shows potent efficacy to suppress central nervous system lymphoma. MedComm (2020). 2023 Nov 4;4(6):e424.
CAS Number
– 2635328-79-7
Molecular Weight
– 478.47
SMILES
– O=C(N1CCC[C@@H](C2=NN(C3=CN=CC(F)=C32)C4=CC=C(C=C4)OC5=C(C(F)=CC=C5)F)C1)C=C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Btk
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
